About midazolam
Benzodiazepine sedative and anaesthetic
Used for
- Sedation before or during procedures
- Induction of general anaesthesia
- Sedation in intensive care
- Treatment of prolonged seizures
Usual adult dose
Varies by use and route; given slowly by a trained clinician, titrated to effect. Intensive-care infusions are individually adjusted.
Usual dose in children
Varies by age, use, and route; given slowly by a trained clinician, titrated to effect.
Common side effects
- Sleepiness and reduced alertness
- Slow or shallow breathing
- Low blood pressure
- Confusion or agitation
Important warnings
- Can cause life-threatening breathing problems, especially with opioids or other sedatives.
- Requires close monitoring and access to breathing support.
- Effects may last longer in older adults or people with liver or kidney problems.
- Can cause dependence and withdrawal after prolonged use.
Pregnancy
Use only when clinically necessary; exposure near delivery may cause newborn sedation, low muscle tone, or breathing problems.
Breastfeeding
May cause infant sleepiness or poor feeding; seek medical guidance about breastfeeding after treatment.
Interactions
- Opioids, alcohol, and sedatives increase drowsiness and breathing suppression.
- Strong CYP3A inhibitors, such as clarithromycin, can prolong or intensify effects.
- CYP3A inducers, such as rifampicin, can reduce effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.