About midazolam
Benzodiazepine sedative and anticonvulsant
Used for
- Rescue treatment for prolonged seizures or seizure clusters.
- Sedation before medical or dental procedures, where appropriate.
Usual adult dose
Seizure rescue dosing depends on the product and route; oromucosal formulations are commonly licensed for children, not adults. Procedural doses are individually adjusted by clinicians.
Usual dose in children
For licensed oromucosal seizure rescue products, dosing is age- and weight-based, usually 2.5–10 mg once; follow the specific product instructions.
Common side effects
- Sleepiness, dizziness, and impaired coordination.
- Breathing may become slow or shallow.
- Nausea or vomiting.
- Paradoxical agitation or unusual behavior.
Important warnings
- Can cause severe breathing problems, especially with opioids, alcohol, or other sedatives.
- Use only as directed; repeat dosing can increase risks.
- Emergency help may be needed if seizures persist or breathing is impaired.
- Can cause dependence and withdrawal with repeated use.
Pregnancy
May harm the unborn baby, particularly with repeated or late-pregnancy use; use only when clinically necessary.
Breastfeeding
Midazolam passes into breast milk in small amounts. Short-term use is generally considered compatible, but monitor for unusual infant sleepiness or poor feeding.
Interactions
- Opioids, alcohol, and sedatives can increase sedation and breathing suppression.
- Strong CYP3A4 inhibitors, such as clarithromycin, may increase midazolam effects.
- CYP3A4 inducers, such as carbamazepine, may reduce its effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.