About flucloxacillin
Penicillinase-resistant penicillin antibiotic
Used for
- Treats susceptible bacterial infections, especially skin and soft-tissue infections.
- May treat bone, joint, or chest infections caused by susceptible bacteria.
Usual adult dose
Usually 250–500 mg by mouth four times daily; dose depends on infection and severity.
Usual dose in children
Usually 12.5–25 mg/kg by mouth four times daily; specialist guidance may vary.
Common side effects
- Nausea, vomiting, or diarrhoea
- Stomach discomfort
- Skin rash or itching
- Rarely, liver inflammation or severe allergic reaction
Important warnings
- Do not use with a serious penicillin allergy.
- Seek urgent help for breathing difficulty or facial swelling.
- Rarely causes serious liver problems, sometimes after treatment ends.
- Take on an empty stomach for best absorption.
Pregnancy
Generally considered suitable when clinically needed; use under healthcare professional guidance.
Breastfeeding
Generally compatible; monitor the infant for diarrhoea, rash, or thrush.
Interactions
- Warfarin: may alter anticoagulant effect; monitoring may be needed.
- Methotrexate: may increase methotrexate levels or toxicity.
- Probenecid: may increase flucloxacillin levels.
- Other antibiotics may affect treatment; check with a healthcare professional.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.