About granisetron
Serotonin 5-HT3 receptor antagonist
Used for
- Prevention and treatment of nausea and vomiting caused by chemotherapy
- Prevention of nausea and vomiting after surgery
Usual adult dose
Chemotherapy: 10 micrograms/kg intravenously before treatment; postoperative nausea: 1 mg intravenously.
Usual dose in children
Chemotherapy: 10 micrograms/kg intravenously before treatment; use varies by age and local guidance.
Common side effects
- Headache
- Constipation or diarrhea
- Dizziness
- Injection-site reactions
Important warnings
- May affect heart rhythm, especially with heart-rhythm conditions or electrolyte problems.
- Use caution with bowel obstruction; it may mask worsening symptoms.
- Rarely causes serotonin syndrome, particularly with other serotonin-raising medicines.
- Seek urgent care for severe allergic reactions.
Pregnancy
Human pregnancy information is limited; use only when clearly needed and prescribed.
Breastfeeding
It is not known whether granisetron passes into breast milk; discuss use with a healthcare professional.
Interactions
- Other medicines that prolong the QT interval may increase heart-rhythm risk.
- Serotonergic medicines may increase serotonin syndrome risk.
- Medicines affecting liver enzymes may alter granisetron levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.