About paliperidone
Atypical antipsychotic
Used for
- Schizophrenia in adults and adolescents
- Schizoaffective disorder in adults
Usual adult dose
Schizophrenia: 6 mg once daily; usual range 3–12 mg daily. Schizoaffective disorder: 6 mg daily; usual range 3–12 mg daily.
Usual dose in children
Schizophrenia, ages 12–17: 3 mg once daily initially; usual range 3–6 mg daily, maximum 12 mg.
Common side effects
- Sleepiness, dizziness, or headache
- Restlessness or movement problems
- Weight gain and increased blood sugar
- Raised prolactin, which may affect periods or sexual function
Important warnings
- May increase risk of death in older adults with dementia-related psychosis; not approved for this use.
- Can cause abnormal movements, including potentially persistent tardive dyskinesia.
- May cause fainting, low blood pressure, or abnormal heart rhythm.
- Do not crush, split, or chew extended-release tablets.
Pregnancy
May cause temporary movement or withdrawal symptoms in newborns after exposure late in pregnancy. Discuss risks with a healthcare professional.
Breastfeeding
Paliperidone passes into breast milk; effects on a nursing infant are uncertain. Consider potential infant exposure with a healthcare professional.
Interactions
- Medicines that cause drowsiness or lower blood pressure may intensify these effects.
- Medicines that prolong the QT interval may increase heart-rhythm risks.
- Carbamazepine can lower paliperidone levels.
- Levodopa and dopamine agonists may have reduced effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.