About dornase alpha
Recombinant human deoxyribonuclease enzyme
Used for
- Thins thick mucus and improves lung function in cystic fibrosis.
- Helps reduce respiratory infections and risk of lung-function decline in cystic fibrosis.
Usual adult dose
Cystic fibrosis: 2.5 mg inhaled by nebulizer once daily; some people use it twice daily.
Usual dose in children
Cystic fibrosis: 2.5 mg inhaled by nebulizer once daily; some children use it twice daily.
Common side effects
- Voice changes or hoarseness
- Sore throat
- Rash
- Chest discomfort or breathing difficulty
Important warnings
- For inhalation only; do not swallow or mix with other nebulized medicines.
- Use the recommended nebulizer and follow its cleaning instructions.
- Sudden breathing difficulty can occur; seek urgent medical care if severe.
- Not established for conditions other than cystic fibrosis.
Pregnancy
Human pregnancy data are limited. Use only when a clinician considers treatment necessary.
Breastfeeding
It is not known whether dornase alfa enters breast milk; systemic absorption is expected to be low.
Interactions
- No specific clinically important medicine interactions are established.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.