About dornase alpha
Recombinant human deoxyribonuclease enzyme
Used for
- Reduces mucus thickness and improves lung function in cystic fibrosis.
- Helps reduce respiratory infections requiring antibiotics in cystic fibrosis.
Usual adult dose
Usually 2.5 mg inhaled once daily; some people use it twice daily.
Usual dose in children
Usually 2.5 mg inhaled once daily; some children use it twice daily.
Common side effects
- Voice changes or hoarseness
- Sore throat
- Rash
- Chest discomfort or shortness of breath
Important warnings
- For inhalation only; do not swallow or mix with other medicines.
- Use with a suitable nebulizer as directed.
- May cause allergic reactions, including rarely severe reactions.
- Not established for other lung diseases or children under five.
Pregnancy
Human pregnancy information is limited. Use only when the expected benefit outweighs potential risk.
Breastfeeding
It is unknown whether dornase alfa enters breast milk; systemic absorption after inhalation is low.
Interactions
- No clinically important medicine interactions are well established.
- Do not mix with other medicines in the nebulizer.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.