About desmopressin acetate
Antidiuretic hormone analogue
Used for
- Central diabetes insipidus
- Bedwetting in children (some nasal products; use is restricted)
Usual adult dose
Central diabetes insipidus: commonly 10–40 micrograms intranasally daily, divided into one or two doses; individualized by response.
Usual dose in children
Central diabetes insipidus: commonly 5–30 micrograms intranasally daily, divided into one or two doses; individualized by response.
Common side effects
- Headache
- Nasal discomfort or congestion
- Nausea
- Low blood sodium, which can be severe
Important warnings
- Excess fluid intake can cause dangerous low blood sodium.
- Seek urgent care for confusion, seizures, severe headache, or vomiting.
- Nasal dosing may be unreliable with congestion or nasal disease.
- Nasal desmopressin is generally not recommended for bedwetting due to hyponatremia risk.
Pregnancy
Use only when needed and under medical supervision; available evidence has not shown a clear increased risk of birth defects.
Breastfeeding
Small amounts may enter breast milk; clinically important effects are unlikely, but use requires clinical review.
Interactions
- Medicines that increase low-sodium risk, including some antidepressants and carbamazepine
- NSAIDs such as ibuprofen may increase water retention
- Other medicines affecting fluid balance or urine output
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.