About prochlorperazine
Phenothiazine antiemetic
Used for
- Severe nausea and vomiting
- Schizophrenia and other psychotic disorders
Usual adult dose
Nausea and vomiting: 25 mg rectally twice daily. Rectal treatment is generally for nausea and vomiting.
Usual dose in children
Not routinely used rectally in children; dosing requires specialist guidance.
Common side effects
- Drowsiness or dizziness
- Dry mouth, blurred vision, constipation
- Restlessness or movement problems
- Low blood pressure
Important warnings
- May cause serious movement disorders, especially with prolonged use.
- Avoid alcohol and activities requiring alertness if drowsy.
- Use caution with heart rhythm problems, seizures, or older age.
- Seek urgent care for fever, muscle stiffness, confusion, or uncontrollable movements.
Pregnancy
Use only when clearly needed; discuss risks and benefits with a healthcare professional.
Breastfeeding
May cause infant drowsiness or affect milk supply; seek professional guidance before use.
Interactions
- Alcohol, opioids, and sedatives increase drowsiness.
- Medicines affecting heart rhythm can increase dangerous rhythm risks.
- Levodopa and dopamine agonists may work less effectively.
- Other antipsychotics or movement-affecting medicines increase side-effect risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.