About domperidone
Dopamine-blocking antiemetic
Used for
- Relief of nausea and vomiting
- Short-term treatment of bloating or upper abdominal discomfort where approved
Usual adult dose
Usually 10 mg up to three times daily, before meals; generally for the shortest duration, often no more than one week.
Usual dose in children
For children weighing under 35 kg, dosing is weight-based and varies by local guidance; use only when specifically prescribed.
Common side effects
- Dry mouth
- Headache
- Abdominal cramps or diarrhea
- Raised prolactin, sometimes causing breast changes
Important warnings
- Can cause serious abnormal heart rhythms, especially with higher doses or prolonged use.
- Risk increases with heart disease, older age, electrolyte imbalance, or interacting medicines.
- Avoid in gastrointestinal bleeding, obstruction, or perforation.
- Use the lowest effective dose for the shortest time.
Pregnancy
Use only if clearly needed and prescribed; safety evidence is limited.
Breastfeeding
Small amounts enter breast milk; it may affect heart rhythm and can increase milk production.
Interactions
- Avoid medicines that prolong the QT interval, including some antibiotics and antipsychotics.
- Avoid strong CYP3A4 inhibitors, such as clarithromycin, ketoconazole, or ritonavir.
- Antacids and acid-reducing medicines can reduce absorption; separate their timing.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.