About carglumic acid
N-acetylglutamate analogue; ammonia-lowering agent
Used for
- Treats high blood ammonia from N-acetylglutamate synthase deficiency.
- Used with other treatments for certain organic acid disorders, including propionic and methylmalonic acidemias.
Usual adult dose
Usually 100–250 mg/kg daily for N-acetylglutamate synthase deficiency; dosing varies by condition and is specialist-directed.
Usual dose in children
Usually 100–250 mg/kg daily for N-acetylglutamate synthase deficiency; dosing varies by condition and is specialist-directed.
Common side effects
- Vomiting
- Fever
- Infections
- Low appetite
Important warnings
- High blood ammonia can be life-threatening and needs urgent medical treatment.
- Treatment and dose require specialist supervision and blood-ammonia monitoring.
- Give with food; follow instructions for preparing and administering the suspension.
Pregnancy
Information is limited; use only when a specialist judges the expected benefit outweighs potential risk.
Breastfeeding
It is unknown whether carglumic acid passes into breast milk; specialist advice is needed.
Interactions
- No well-established clinically significant interactions are known.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.