About megestrol acetate
Progestin hormone medicine
Used for
- Treats loss of appetite and severe weight loss in certain illnesses.
- Treats advanced breast or endometrial cancer in selected cases.
Usual adult dose
Appetite loss: usually 400–800 mg daily. Cancer dosing varies by condition and formulation.
Common side effects
- Weight gain and increased appetite
- Fluid retention and swelling
- Nausea or diarrhea
- Raised blood sugar
Important warnings
- May increase blood-clot risk.
- Can suppress adrenal function; serious problems may occur when stopping or during illness.
- May worsen diabetes or cause new diabetes.
- Not a contraceptive; pregnancy should be avoided during treatment.
Pregnancy
Avoid during pregnancy; it may harm the fetus.
Breastfeeding
Avoid during breastfeeding; safety is not established.
Interactions
- Warfarin: may alter anticoagulant effects; monitor closely.
- Diabetes medicines: megestrol may worsen blood sugar control.
- Some enzyme-inducing medicines, such as rifampin, may reduce its effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.