About voriconaz ole
Triazole antifungal
Used for
- Treats serious fungal infections, including invasive aspergillosis and candidiasis.
- Treats certain serious infections caused by Scedosporium or Fusarium fungi.
Usual adult dose
Usually 6 mg/kg every 12 hours for two doses, then 4 mg/kg every 12 hours; oral dosing is adjusted by indication and response.
Usual dose in children
For ages 2–14 years and younger adolescents under 50 kg: usually 9 mg/kg every 12 hours for two doses, then 8 mg/kg every 12 hours orally.
Common side effects
- Visual changes, headache, or dizziness
- Nausea, vomiting, or diarrhea
- Rash or sun sensitivity
- Abnormal liver tests
Important warnings
- Can cause serious liver injury; monitoring is needed.
- May cause serious skin reactions and increased sun-related skin damage.
- Can affect heart rhythm and cause visual or neurological effects.
- Dose and formulation depend on age, weight, infection, and liver function.
Pregnancy
May harm an unborn baby; generally avoided during pregnancy unless essential.
Breastfeeding
Breastfeeding safety is uncertain; discuss risks with a healthcare professional.
Interactions
- Many interactions, including rifampicin, carbamazepine, and St John’s wort, which can make treatment ineffective.
- Can raise levels of warfarin, some statins, and certain sedatives.
- Some medicines, including sirolimus and certain migraine ergot medicines, must not be combined.
- Acid-reducing medicines and other antifungals may affect treatment.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.