About lamivudine
Nucleoside reverse transcriptase inhibitor
Used for
- Treatment of HIV infection with other antiretroviral medicines
- Treatment of chronic hepatitis B
Usual adult dose
HIV: usually 300 mg daily or 150 mg twice daily. Hepatitis B: usually 100 mg daily.
Usual dose in children
HIV: usually 4 mg/kg twice daily, maximum 300 mg daily; dosing depends on age and weight.
Common side effects
- Headache, nausea, or diarrhea
- Tiredness
- Liver inflammation
- Rarely, lactic acid buildup or severe liver enlargement
Important warnings
- Different dosing is used for HIV and hepatitis B.
- Stopping treatment for hepatitis B can worsen liver disease.
- Dose adjustment may be needed with reduced kidney function.
- HIV treatment should use other antiretroviral medicines as prescribed.
Pregnancy
Lamivudine is used during pregnancy when indicated; treatment decisions depend on the infection and clinical circumstances.
Breastfeeding
HIV guidance generally recommends avoiding breastfeeding to prevent transmission. For hepatitis B, discuss breastfeeding with a clinician.
Interactions
- Trimethoprim can increase lamivudine levels.
- Do not combine with emtricitabine.
- Sorbitol-containing medicines may reduce lamivudine absorption.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.