About selegiline hydrochloride
Monoamine oxidase-B inhibitor
Used for
- Treats Parkinson’s disease, usually alongside levodopa.
Usual adult dose
Usually 5 mg twice daily, taken at breakfast and lunch; dosing depends on the treatment plan.
Common side effects
- Nausea or dizziness
- Insomnia
- Dry mouth
- Low blood pressure when standing
Important warnings
- Can worsen involuntary movements or confusion when combined with levodopa.
- Higher doses may reduce selectivity and increase serious interaction risks.
- Do not stop suddenly without medical guidance.
- Use caution with high blood pressure or heart rhythm problems.
Pregnancy
Human pregnancy information is limited; use only when expected benefits justify potential risks.
Breastfeeding
Breastfeeding safety is uncertain; selegiline may affect milk production. Avoid unless a clinician recommends it.
Interactions
- Avoid with meperidine, tramadol, methadone, and some other opioids.
- Risky with certain antidepressants, including SSRIs, SNRIs, and tricyclics.
- Avoid dextromethorphan and stimulants unless specifically approved.
- Large amounts of tyramine-rich foods may raise blood pressure, especially at higher doses.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.