About hydroxyprogesterone caproate
Long-acting progestin hormone
Used for
- Historically used to reduce recurrent preterm birth risk in selected pregnancies.
- Used in some countries for menstrual disorders or threatened miscarriage.
Usual adult dose
Historically, 250 mg intramuscularly weekly, starting at 16–20 weeks and continuing to 37 weeks or delivery; availability and recommendations vary.
Common side effects
- Injection-site pain or swelling
- Itching or rash
- Nausea
- Fluid retention
Important warnings
- Not recommended in the United States for preventing recurrent preterm birth; benefit has not been confirmed.
- Avoid with active or past blood clots, significant liver disease, or hormone-sensitive cancers.
- May cause allergic reactions or injection-site complications.
- Use during pregnancy only for an established indication.
Pregnancy
Historically used during pregnancy for preterm-birth prevention in selected patients; evidence and recommendations vary by country.
Breastfeeding
Information is limited; hormone may affect milk production. Use depends on clinical need and local product guidance.
Interactions
- Medicines that affect liver enzymes may alter hormone levels.
- Tell clinicians about all medicines, including herbal products.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.