About esomepraz ole
Proton pump inhibitor
Used for
- Treats acid reflux when oral treatment is unsuitable
- Treats inflammation of the food pipe caused by acid
- Prevents recurrent bleeding after endoscopic treatment of stomach ulcers
Usual adult dose
Usually 20–40 mg intravenously once daily. After ulcer bleeding: 80 mg infusion, then 8 mg/hour for 72 hours.
Usual dose in children
Intravenously once daily: 1–11 months, 0.5 mg/kg; 1–11 years, 10–20 mg according to weight; 12–17 years, 20–40 mg.
Common side effects
- Headache
- Nausea, stomach pain, or wind
- Diarrhea or constipation
- Injection-site irritation
Important warnings
- Severe liver disease may require a lower dose
- Rarely causes serious allergic reactions or kidney inflammation
- Persistent diarrhea may indicate a bowel infection
- Prolonged treatment may lower magnesium and increase fracture risk
Pregnancy
Available evidence does not suggest major pregnancy risks, but experience with esomeprazole is limited.
Breastfeeding
Limited evidence suggests low levels in breast milk; effects on breastfed infants are not well studied.
Interactions
- Clopidogrel: may reduce its protective effect
- Rilpivirine or nelfinavir: must not be combined
- High-dose methotrexate: may increase toxicity
- Warfarin, digoxin, or phenytoin: monitoring may be needed
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.