About berotralstat
Plasma kallikrein inhibitor
Used for
- Prevention of hereditary angioedema attacks in adults and children aged 12 years and older
Usual adult dose
150 mg by mouth once daily with food.
Usual dose in children
Ages 12 years and older: 150 mg by mouth once daily with food.
Common side effects
- Abdominal pain
- Vomiting
- Diarrhea
- Back pain
Important warnings
- Not for treating acute hereditary angioedema attacks.
- Higher doses can increase heart rhythm risks.
- Avoid with moderate or severe liver impairment.
- Avoid with severe kidney impairment or end-stage kidney disease.
Pregnancy
Human pregnancy information is limited; use only when potential benefit justifies potential risk.
Breastfeeding
It is unknown whether berotralstat passes into breast milk; discuss potential risks and benefits with a healthcare professional.
Interactions
- May increase levels of CYP2D6 and CYP3A4 substrate medicines.
- Strong CYP3A4 inducers can reduce berotralstat levels and effectiveness.
- Avoid P-glycoprotein or BCRP inhibitors, which can increase berotralstat exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.