About imipramine hydrochloride
Tricyclic antidepressant
Used for
- Depression
- Night-time bedwetting in children
Usual adult dose
Depression: usually 75–150 mg daily, adjusted gradually; maximum commonly 200 mg daily under supervision.
Usual dose in children
Bedwetting: ages 6–12, usually 25–50 mg at bedtime; ages 12 and older, 25–75 mg at bedtime. Not for children under 6.
Common side effects
- Dry mouth, constipation, blurred vision, and difficulty urinating
- Drowsiness, dizziness, sweating, and weight changes
- Fast heartbeat or changes in heart rhythm
- Confusion or agitation, especially in older adults
Important warnings
- Overdose can be fatal; keep securely away from children.
- May increase suicidal thoughts, especially early in treatment or after dose changes.
- Can cause dangerous heart rhythm problems; extra caution with heart disease.
- Do not stop suddenly; withdrawal symptoms may occur.
Pregnancy
Use only when the expected benefit outweighs potential risks; discuss with a healthcare professional.
Breastfeeding
Passes into breast milk; seek professional advice, especially when nursing a newborn or premature infant.
Interactions
- MAO inhibitors: serious reactions; avoid combining and allow an appropriate washout period.
- Other serotonergic medicines may increase serotonin syndrome risk.
- Heart-rhythm medicines and other drugs affecting heart rhythm may increase cardiac risks.
- Alcohol, opioids, and sedatives can worsen drowsiness and impairment.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.