About sorafenib tosylat
Multikinase inhibitor anticancer medicine
Used for
- Treats advanced kidney cancer
- Treats unresectable liver cancer
- Treats radioactive iodine-resistant thyroid cancer
Usual adult dose
Usually 400 mg by mouth twice daily, taken without food; dosing may be adjusted.
Common side effects
- Diarrhea
- Hand-foot skin reaction
- Rash
- High blood pressure
Important warnings
- Can cause severe bleeding, liver injury, heart problems, or skin reactions.
- May delay wound healing; treatment is usually paused around major surgery.
- Can harm an unborn baby; effective contraception is needed during treatment.
- Blood pressure and liver function require monitoring.
Pregnancy
Can cause fetal harm; avoid during pregnancy.
Breastfeeding
Breastfeeding is not recommended during treatment or for two weeks after the last dose.
Interactions
- Warfarin may increase bleeding risk; monitor closely.
- Strong CYP3A4 inducers, such as rifampin, may lower sorafenib levels.
- Some medicines affecting drug transport or metabolism may alter sorafenib exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.