About dapagliflozin
Sodium-glucose cotransporter-2 (SGLT2) inhibitor
Used for
- Type 2 diabetes, alongside diet and exercise
- Heart failure, including reduced ejection fraction
- Chronic kidney disease to reduce worsening and related risks
Usual adult dose
Usually 10 mg once daily for diabetes, heart failure, or chronic kidney disease; diabetes may start at 5 mg.
Usual dose in children
For type 2 diabetes from age 10: usually 5 mg once daily, increasing to 10 mg if needed and tolerated.
Common side effects
- Genital yeast infections
- Urinary tract infections
- Increased urination
- Dehydration or low blood pressure
Important warnings
- Can rarely cause diabetic ketoacidosis, sometimes with near-normal blood sugar.
- Risk of dehydration, especially with illness, fasting, or diuretics.
- Not recommended for type 1 diabetes; kidney function affects use for diabetes.
- Seek urgent care for severe genital or perineal pain, redness, or swelling.
Pregnancy
Generally avoid, especially during the second and third trimesters, because of possible harm to fetal kidney development.
Breastfeeding
Not recommended; it may affect kidney development in a nursing infant.
Interactions
- Insulin or sulfonylureas may increase low blood sugar risk.
- Diuretics may increase dehydration or low blood pressure.
- Lithium levels may be reduced; monitoring may be needed.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.