About plerixafor
Stem cell mobilizer; CXCR4 antagonist
Used for
- Mobilizes blood-forming stem cells for collection before transplant in certain blood cancers.
Usual adult dose
Usually 0.24 mg/kg injected under the skin once daily, with a growth factor, before stem-cell collection; kidney impairment may require adjustment.
Usual dose in children
Specialist-directed dosing for children aged 1 year and older; based on body weight and kidney function.
Common side effects
- Diarrhea, nausea, vomiting, or abdominal pain
- Injection-site reactions
- Fatigue, headache, dizziness, or joint pain
- Low blood pressure or increased white blood cell counts
Important warnings
- Can cause severe allergic reactions, including anaphylaxis.
- May enlarge the spleen; seek assessment for left upper abdominal or shoulder pain.
- May mobilize cancer cells; use only under specialist supervision.
- Dose adjustment is needed with impaired kidney function.
Pregnancy
May harm an unborn baby; pregnancy should be avoided during treatment, with contraception discussed with a clinician.
Breastfeeding
It is not known whether plerixafor passes into breast milk; breastfeeding is generally avoided during treatment.
Interactions
- Other medicines that affect blood cell counts may require monitoring.
- No major drug interactions are established; provide the treatment team with a full medicine list.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.