About idarucizumab
Direct thrombin inhibitor reversal agent
Used for
- Reverses dabigatran when emergency surgery or urgent procedures are needed.
- Reverses dabigatran during life-threatening or uncontrolled bleeding.
Usual adult dose
5 g intravenously, given as two consecutive 2.5 g doses.
Common side effects
- Headache
- Low blood potassium
- Confusion
- Constipation
Important warnings
- Dabigatran’s effects may return, especially with impaired kidney function.
- Blood clots can occur after reversal; restart anticoagulation when clinically appropriate.
- Use only when dabigatran reversal is clinically necessary.
Pregnancy
Human pregnancy data are limited; use only when clinically necessary.
Breastfeeding
It is unknown whether idarucizumab enters breast milk; consider clinical need and infant exposure.
Interactions
- May reverse dabigatran, reducing its anticoagulant effect.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.