About ondansetr on
5-HT3 serotonin receptor antagonist
Used for
- Prevention and treatment of nausea and vomiting from chemotherapy
- Prevention of nausea and vomiting after surgery
Usual adult dose
Usually 8 mg before chemotherapy, then 8 mg every 12 hours; postoperative dosing varies.
Usual dose in children
For chemotherapy, usually 0.15 mg/kg per dose, up to 8 mg, before treatment and at intervals afterward; specialist protocols vary.
Common side effects
- Headache
- Constipation
- Diarrhoea
- Dizziness
Important warnings
- May prolong the heart rhythm and rarely cause dangerous arrhythmias.
- Avoid with apomorphine; the combination can cause severe low blood pressure and loss of consciousness.
- Seek urgent care for allergic reactions or symptoms of serotonin syndrome.
- Use caution with severe liver disease; maximum daily dose may need limiting.
Pregnancy
Use only when clinically needed; discuss risks and benefits with a healthcare professional.
Breastfeeding
Information is limited; discuss use with a healthcare professional.
Interactions
- Apomorphine
- Medicines that prolong the QT interval
- Serotonergic medicines, including some antidepressants
- Strong enzyme-inducing medicines, such as rifampicin
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.