About hydromorphone hydrochloride
Extended-release opioid analgesic
Used for
- Severe, persistent pain requiring continuous opioid treatment
Usual adult dose
Individualized; typically taken once daily. Dose depends on prior opioid use and response.
Common side effects
- Constipation
- Nausea and vomiting
- Drowsiness or dizziness
- Itching
Important warnings
- Can cause fatal slowed breathing, especially when starting or increasing doses.
- Risk of dependence, misuse, and overdose; do not share.
- Swallow tablets whole; crushing or chewing can release a dangerous dose.
- Avoid alcohol and sedatives unless specifically directed by a clinician.
Pregnancy
Use only when clearly necessary; prolonged use can cause newborn withdrawal. Opioids near delivery may affect the newborn’s breathing.
Breastfeeding
Not recommended; hydromorphone can pass into milk and may cause infant sleepiness or breathing problems.
Interactions
- Alcohol, benzodiazepines, and other sedatives increase sedation and breathing risk.
- Other opioids increase overdose risk.
- Some medicines affecting CYP3A4 can alter hydromorphone exposure.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.