About mirtazapine
Tetracyclic antidepressant
Used for
- Major depressive disorder
Usual adult dose
Usually 15 mg once daily at bedtime; may be increased gradually to 45 mg daily.
Common side effects
- Sleepiness
- Increased appetite and weight gain
- Dry mouth
- Dizziness
Important warnings
- May increase suicidal thoughts, especially in young adults.
- Can cause severe low white blood cell counts; seek care for fever or sore throat.
- May trigger mania in people with bipolar disorder.
- Avoid abrupt stopping; withdrawal symptoms can occur.
Pregnancy
Use during pregnancy only when benefits outweigh risks; discuss potential newborn effects with a clinician.
Breastfeeding
Passes into breast milk; may cause infant sleepiness. Discuss risks and benefits with a clinician.
Interactions
- MAO inhibitors: dangerous interaction; avoid during treatment and for 14 days around use.
- Alcohol and sedatives can worsen sleepiness and impaired coordination.
- Other serotonin-raising medicines may increase serotonin syndrome risk.
- Some medicines, including carbamazepine, can alter mirtazapine levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.