About vandetanib
Tyrosine kinase inhibitor
Used for
- Treatment of symptomatic or progressive, unresectable locally advanced or metastatic medullary thyroid cancer.
Usual adult dose
300 mg by mouth once daily; dose adjustment may be needed for side effects or kidney problems.
Usual dose in children
For children aged 5 years and older with advanced medullary thyroid cancer: dose is based on body-surface area and specialist guidance.
Common side effects
- Diarrhea
- Rash and other skin reactions
- High blood pressure
- Prolonged QT interval
Important warnings
- Can cause serious heart-rhythm changes; ECG and electrolyte monitoring are required.
- Diarrhea, lung inflammation, and severe skin reactions can occur.
- May cause bleeding, heart failure, or reversible posterior leukoencephalopathy syndrome.
- Long-lasting effects; avoid pregnancy during treatment and for at least four months afterward.
Pregnancy
May harm an unborn baby. Avoid pregnancy during treatment and for at least four months after the last dose.
Breastfeeding
Breastfeeding is not recommended during treatment or for at least four months after the last dose.
Interactions
- QT-prolonging medicines can increase the risk of dangerous heart rhythms.
- Strong CYP3A4 inducers, such as rifampicin, can reduce vandetanib levels.
- Medicines that increase stomach pH may reduce absorption.
- Digoxin levels may increase; monitoring may be needed.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.