About sirolimus
mTOR inhibitor immunosuppressant
Used for
- Prevention of kidney transplant rejection, usually with other immunosuppressants.
- Treatment of lymphangioleiomyomatosis, a rare lung disease.
Usual adult dose
Kidney transplant: typically 2 mg once daily after a loading dose; adjusted using blood levels. Lymphangioleiomyomatosis: 2 mg once daily.
Usual dose in children
Kidney transplant: dosing is individualized by age, body size, and blood levels; specialist supervision is required.
Common side effects
- Infections and increased infection risk
- Mouth sores, diarrhea, or nausea
- High cholesterol or triglycerides
- Swelling, acne, or delayed wound healing
Important warnings
- Can cause serious infections and increase the risk of some cancers.
- May impair wound healing and cause fluid buildup around the lungs.
- Requires blood tests and monitoring of drug levels.
- Do not stop or change treatment without transplant-team guidance.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for 12 weeks after stopping.
Breastfeeding
Breastfeeding is not recommended during treatment because of potential serious effects on the infant.
Interactions
- Strong CYP3A4 or P-glycoprotein inhibitors can raise sirolimus levels.
- Strong CYP3A4 or P-glycoprotein inducers can lower sirolimus levels.
- Grapefruit and grapefruit juice can increase sirolimus levels.
- Live vaccines may be unsafe or less effective during treatment.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.