About clomiprami ne
Tricyclic antidepressant
Used for
- Obsessive-compulsive disorder
- Depression
- Panic disorder and other anxiety disorders
Usual adult dose
Usually starts at 25 mg daily, then increases gradually; maintenance commonly 100–250 mg daily, depending on condition.
Usual dose in children
For obsessive-compulsive disorder, ages 10 and older: usually starts at 25 mg daily; increased gradually to a maximum of 200 mg daily or 3 mg/kg, whichever is lower.
Common side effects
- Dry mouth, constipation, blurred vision
- Drowsiness, dizziness, sweating
- Nausea, weight gain
- Fast heartbeat or changes in heart rhythm
Important warnings
- Can increase suicidal thoughts, especially in young people early in treatment.
- Do not stop suddenly; withdrawal symptoms can occur.
- May cause seizures, low blood pressure, or serious heart-rhythm problems.
- Seek urgent help for overdose or symptoms of serotonin syndrome.
Pregnancy
Use during pregnancy requires individual assessment; late-pregnancy exposure may affect the newborn.
Breastfeeding
Clomipramine enters breast milk. Use requires clinical assessment and monitoring of the infant.
Interactions
- MAO inhibitors: risk of severe reactions; avoid combined use.
- Other serotonergic medicines, including SSRIs and tramadol: serotonin syndrome risk.
- Medicines that prolong QT or affect heart rhythm: increased risk.
- Alcohol and sedatives: increased drowsiness and impaired coordination.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.