About desmopres sin acetate
Synthetic vasopressin analogue
Used for
- Central diabetes insipidus
- Bleeding disorders, including haemophilia A and von Willebrand disease
- Reducing excessive urination during certain procedures
Usual adult dose
For central diabetes insipidus, commonly 1–4 micrograms by injection, repeated as needed under specialist supervision. Bleeding-disorder doses depend on the condition and procedure.
Usual dose in children
For central diabetes insipidus, commonly 0.1–1 microgram by injection; specialists adjust the dose. Bleeding-disorder dosing is individualised.
Common side effects
- Headache
- Nausea or stomach cramps
- Flushing
- Fluid retention and low blood sodium
Important warnings
- Can cause dangerously low blood sodium, seizures, or confusion, especially with excess fluids.
- Fluid intake may need restriction; follow the treating team’s instructions.
- Use caution with kidney or heart disease and medicines that affect sodium or fluid balance.
- Not all bleeding disorders respond; testing and specialist supervision may be needed.
Pregnancy
May be used when clinically needed; evidence is limited. The reason for treatment and fluid balance require medical supervision.
Breastfeeding
Small amounts may enter breast milk; available evidence suggests low risk, but clinical supervision is appropriate.
Interactions
- Medicines increasing low-sodium risk, such as some antidepressants and carbamazepine
- NSAIDs, such as ibuprofen, may increase water retention
- Lithium may reduce desmopressin’s effect
- Other medicines affecting fluid balance or kidney function
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.