About acetaminophen + diphenhydramine hcl
Analgesic and sedating antihistamine
Used for
- Relieves pain and fever
- Diphenhydramine may cause drowsiness and help with occasional sleeplessness
Usual adult dose
For pain or fever, follow the product label; for occasional sleeplessness, commonly 25–50 mg diphenhydramine at bedtime. Avoid combining products containing either ingredient.
Common side effects
- Drowsiness
- Dry mouth
- Dizziness
- Nausea
Important warnings
- May impair alertness; avoid driving or alcohol.
- Do not exceed the paracetamol limit or combine with other paracetamol-containing medicines.
- Diphenhydramine can cause confusion or urinary problems, especially in older adults.
- Seek urgent help for suspected overdose, even if there are no symptoms.
Pregnancy
Use only when needed and with healthcare-professional guidance; avoid routine diphenhydramine use without advice.
Breastfeeding
Paracetamol is generally compatible; diphenhydramine may cause infant drowsiness or reduce milk supply, especially with repeated use.
Interactions
- Alcohol, sedatives, and opioids can increase drowsiness.
- Other paracetamol-containing medicines increase liver-damage risk.
- Diphenhydramine interacts with MAO inhibitors and other medicines causing sedation or anticholinergic effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.