About siponimod
Selective sphingosine-1-phosphate receptor modulator
Used for
- Treats relapsing forms of multiple sclerosis in adults, including active secondary progressive disease.
Usual adult dose
Dose is increased gradually over five days, then usually 2 mg once daily; some people require 1 mg daily based on genetic testing.
Common side effects
- Headache
- High blood pressure
- Liver enzyme increases
- Slow heart rate
Important warnings
- Genetic testing is needed to determine the appropriate maintenance dose.
- May cause serious infections; screening and monitoring are required.
- Can cause heart-rate changes, eye swelling, and liver injury.
- Stopping treatment can rarely cause severe worsening of multiple sclerosis.
Pregnancy
May harm an unborn baby. Effective contraception is recommended during treatment and for 10 days after stopping.
Breastfeeding
It is not known whether siponimod passes into human milk; discuss potential risks with a healthcare professional.
Interactions
- Medicines that slow heart rate or affect heart rhythm may increase cardiac risks.
- Other immune-suppressing medicines may increase infection risk.
- Strong CYP2C9 or CYP3A4 inhibitors or inducers can alter siponimod levels.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.