About mavacamte n
Cardiac myosin inhibitor
Used for
- Treats adults with symptomatic obstructive hypertrophic cardiomyopathy to improve symptoms and functional ability.
Usual adult dose
Usually 2.5 mg once daily; adjusted by echocardiogram-guided monitoring, up to 15 mg daily.
Common side effects
- Dizziness
- Fainting
- Heart failure
- Serious allergic reactions
Important warnings
- Can weaken heart contraction and cause heart failure; regular echocardiograms are required.
- Do not start or increase without specialist monitoring.
- Avoid pregnancy; effective contraception is required during treatment and for four months afterward.
- Not recommended with certain heart-rhythm conditions or moderate-to-strong CYP2C19/CYP3A4 inhibitors.
Pregnancy
May harm the fetus. Avoid during pregnancy; use effective contraception during treatment and for four months after stopping.
Breastfeeding
Unknown whether mavacamten passes into breast milk; breastfeeding is not recommended during treatment and for four months after stopping.
Interactions
- Some antifungals, antibiotics, and heart medicines can raise mavacamten levels.
- Strong CYP2C19 or CYP3A4 inducers can lower levels and reduce effectiveness.
- Other medicines that weaken heart contraction may increase heart-failure risk.
- Tell clinicians about all medicines, including supplements, before treatment changes.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.