About nitisinone
Tyrosine-metabolism inhibitor
Used for
- Hereditary tyrosinemia type 1
- Alkaptonuria in adults
Usual adult dose
Tyrosinemia: usually 1 mg/kg daily, adjusted to blood tests. Alkaptonuria: 10 mg once daily.
Usual dose in children
Tyrosinemia: usually 1 mg/kg daily, adjusted to blood tests. Not used for alkaptonuria in children.
Common side effects
- Low platelet or white blood cell counts
- Eye irritation or corneal inflammation
- Rash and itching
- Raised liver enzymes
Important warnings
- Tyrosinemia treatment requires a restricted tyrosine and phenylalanine diet.
- Regular blood and eye checks are needed.
- Can cause severe eye problems if blood tyrosine becomes high.
- Use only under specialist medical supervision.
Pregnancy
Use only when the expected benefit outweighs potential risks; specialist oversight is needed.
Breastfeeding
Breastfeeding is generally not recommended during treatment.
Interactions
- No major established drug interactions are commonly reported.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.