About ezetimibe
Cholesterol absorption inhibitor
Used for
- Lowers LDL cholesterol with diet, alone or alongside a statin.
- Treats inherited high cholesterol, including familial hypercholesterolemia.
- Reduces cardiovascular risk in certain people when added to statin therapy.
Usual adult dose
10 mg by mouth once daily, with or without food.
Usual dose in children
Ages 10 years and older: 10 mg by mouth once daily for inherited high cholesterol. Not established for younger children.
Common side effects
- Diarrhea or stomach discomfort
- Joint or muscle pain
- Tiredness
- Raised liver enzymes, especially with statins
Important warnings
- Report unexplained muscle pain, tenderness, or weakness.
- Liver tests may be needed, particularly when used with a statin.
- Avoid with moderate or severe liver disease.
- Bile-acid medicines can reduce absorption; separate doses by at least two hours before or four hours after.
Pregnancy
Human pregnancy information is limited; use only when the expected benefit justifies potential risk.
Breastfeeding
It is unknown whether ezetimibe enters breast milk; discuss benefits and risks with a healthcare professional.
Interactions
- Cyclosporine can increase ezetimibe levels.
- Fibrates may increase gallstone risk and can raise ezetimibe levels.
- Warfarin may require closer monitoring of clotting tests.
- Bile-acid sequestrants reduce absorption unless doses are separated.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.