About lopinavir + ritonavir
HIV protease inhibitor combination
Used for
- Treatment of HIV-1 infection, combined with other antiretroviral medicines.
Usual adult dose
Usually 400 mg lopinavir/100 mg ritonavir twice daily, with or without food.
Usual dose in children
For children aged 14 days or older, dosing is based on weight or body surface area and other medicines; specialist guidance is required.
Common side effects
- Diarrhea, nausea, or vomiting
- Raised cholesterol or triglycerides
- Liver enzyme changes
- Rash or abdominal discomfort
Important warnings
- Can cause serious liver problems; risk is higher with existing liver disease.
- May affect heart rhythm or electrical conduction, especially with certain conditions or medicines.
- Can raise blood sugar and cause changes in body fat.
- Do not stop or change HIV treatment without medical supervision.
Pregnancy
Combination therapy can be used during pregnancy when clinically indicated; dosing may need adjustment. Specialist monitoring is important.
Breastfeeding
HIV can pass through breast milk. Breastfeeding recommendations depend on local guidance and individual circumstances.
Interactions
- Many medicines interact because ritonavir strongly affects drug-metabolizing enzymes.
- Avoid certain medicines, including simvastatin, lovastatin, and oral midazolam.
- Rifampicin and St John’s wort can reduce treatment levels.
- Some medicines, including anticoagulants and seizure treatments, may need monitoring or adjustment.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.