About fostamatinib
Spleen tyrosine kinase inhibitor
Used for
- Treats chronic immune thrombocytopenia in adults when other treatments have not worked well enough.
Usual adult dose
100 mg by mouth twice daily; may increase to 150 mg twice daily after four weeks if needed and tolerated.
Common side effects
- Diarrhea
- High blood pressure
- Nausea
- Liver enzyme increases
Important warnings
- Can cause serious liver injury; liver tests are monitored during treatment.
- May cause severe diarrhea, high blood pressure, or low neutrophil counts.
- Can increase infection risk; report signs of infection.
- May cause fetal harm; effective contraception is recommended during treatment and for at least one month afterward.
Pregnancy
May cause fetal harm based on animal studies; human pregnancy information is limited.
Breastfeeding
Breastfeeding is not recommended during treatment and for at least one month after the last dose.
Interactions
- Strong CYP3A4 inhibitors can increase fostamatinib exposure.
- Strong CYP3A4 inducers can reduce fostamatinib exposure.
- Fostamatinib can increase exposure to certain medicines, including simvastatin, rosuvastatin, and digoxin.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.