About sparsentan
Endothelin and angiotensin receptor blocker
Used for
- Slows kidney function decline in adults with IgA nephropathy at risk of progression
Usual adult dose
Start 200 mg once daily for 14 days, then 400 mg once daily if tolerated.
Common side effects
- Swelling or fluid retention
- Low blood pressure, dizziness
- High potassium
- Liver enzyme abnormalities
Important warnings
- Can cause liver injury; monitor liver tests before and during treatment.
- Can cause fetal harm; pregnancy must be excluded and effective contraception used.
- May worsen fluid retention or heart failure.
- Monitor kidney function and potassium; avoid use with severe liver impairment.
Pregnancy
Contraindicated; may cause fetal harm. Use effective contraception during treatment and for one month afterward.
Breastfeeding
Breastfeeding is not recommended during treatment and for one month after stopping.
Interactions
- Do not combine with other angiotensin receptor blockers or endothelin receptor antagonists.
- Avoid aliskiren, especially in people with diabetes or kidney impairment.
- Strong CYP3A inhibitors can raise sparsentan levels; avoid combination.
- NSAIDs may increase kidney injury risk; potassium supplements may increase potassium.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.