About procarbazine
Alkylating antineoplastic medicine
Used for
- Used with other cancer medicines, especially for Hodgkin lymphoma and certain brain tumors.
Usual adult dose
Hodgkin lymphoma regimens commonly use 100 mg/m² by mouth daily on days 1–14 of a 28-day cycle; dosing varies by regimen.
Usual dose in children
Specialist-directed dosing varies by cancer and treatment regimen; there is no single standard dose.
Common side effects
- Nausea, vomiting, loss of appetite
- Low blood counts and increased infection or bleeding risk
- Tingling or numbness
- Drowsiness, dizziness, or confusion
Important warnings
- Can cause severe bone marrow suppression; blood tests are needed during treatment.
- May impair fertility and can harm an unborn baby; effective contraception is important.
- Avoid alcohol and tyramine-rich foods, such as aged cheese, unless the oncology team advises otherwise.
- Report fever, unusual bleeding, severe headache, or allergic symptoms promptly.
Pregnancy
May cause fetal harm. Avoid during pregnancy; discuss reliable contraception and pregnancy planning with the oncology team.
Breastfeeding
Breastfeeding is not recommended during treatment because of potential serious harm to the infant.
Interactions
- Other medicines that suppress bone marrow can increase infection and bleeding risks.
- Some antidepressants, stimulants, and decongestants may cause dangerous blood pressure or nervous-system effects.
- Alcohol and tyramine-rich foods may trigger flushing, headache, or high blood pressure.
- Live vaccines may cause infection during treatment; ask the oncology team before vaccination.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.