About paclitaxel
Taxane chemotherapy medicine
Used for
- Treats breast, ovarian, and non-small-cell lung cancers
- Treats advanced AIDS-related Kaposi sarcoma
Usual adult dose
Varies by cancer and treatment combination; commonly 135–175 mg/m² intravenously every 3 weeks.
Common side effects
- Low blood counts and increased infection risk
- Hair loss
- Nausea, vomiting, or diarrhea
- Nerve damage, muscle aches, or allergic reactions
Important warnings
- Given by infusion under specialist supervision; premedication helps prevent severe allergic reactions.
- Blood counts and liver function need monitoring; doses may require adjustment.
- Can cause severe fetal harm; effective contraception is needed during treatment.
- The injection contains alcohol and may cause reactions in people sensitive to it.
Pregnancy
May cause fetal harm. Avoid during pregnancy; contraception is recommended during treatment and for a period afterward.
Breastfeeding
Breastfeeding is not recommended during treatment and for a period afterward.
Interactions
- CYP2C8 or CYP3A4 inhibitors may increase paclitaxel exposure.
- CYP2C8 or CYP3A4 inducers may reduce paclitaxel exposure.
- Cisplatin can increase paclitaxel exposure and toxicity, depending on treatment sequence.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.