About phenelzine sulfate
Monoamine oxidase inhibitor antidepressant
Used for
- Depression, especially when other treatments have not worked
Usual adult dose
Usually 15 mg three times daily; adjusted gradually, typically 45–90 mg daily.
Common side effects
- Dizziness, drowsiness, or weakness
- Low blood pressure, especially when standing
- Weight gain or sexual problems
- Insomnia or headache
Important warnings
- Avoid foods high in tyramine; dangerous blood pressure rises can occur.
- Many medicines interact, including antidepressants, stimulants, and some pain or cold medicines.
- Can cause suicidal thoughts, especially when treatment starts or doses change.
- Do not stop suddenly; tapering is generally needed.
Pregnancy
Use only when clearly needed; discuss risks and benefits with a clinician, as evidence is limited.
Breastfeeding
May enter breast milk; breastfeeding is generally not recommended during treatment.
Interactions
- Tyramine-rich foods, such as aged cheese and cured meats
- Other antidepressants, including SSRIs and SNRIs
- Stimulants and decongestants, including pseudoephedrine
- Opioids such as meperidine and tramadol
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.