About calcium folinate
Folinic acid (reduced folate)
Used for
- Reduces harm from methotrexate and other folate-blocking medicines.
- Treats folate-deficiency megaloblastic anemia when folic acid cannot be used.
- Used with fluorouracil to treat certain colorectal cancers.
Usual adult dose
Depends on use. Methotrexate rescue is usually given by injection, commonly starting 15 mg every 6 hours; cancer treatment doses vary by regimen.
Usual dose in children
Methotrexate rescue dosing is based on body size and blood levels; specialist-directed.
Common side effects
- Nausea, vomiting, or diarrhea
- Rash, itching, or hives
- Rare severe allergic reactions
- With fluorouracil, increased diarrhea and mouth sores
Important warnings
- Methotrexate rescue dosing must follow the chemotherapy plan and laboratory results.
- It can reduce the effect of some folate-blocking medicines if used incorrectly.
- Fluorouracil combinations can cause severe or life-threatening toxicity.
- Capsules may not be suitable for urgent methotrexate rescue, which often requires injection.
Pregnancy
Safety depends on the reason for use and other medicines. Methotrexate is harmful in pregnancy; specialist assessment is essential.
Breastfeeding
Advice depends on the treatment regimen, especially with chemotherapy. Seek specialist guidance before use.
Interactions
- Methotrexate and other folate-blocking medicines
- Fluorouracil and related chemotherapy medicines
- Some anti-seizure medicines, including phenytoin and phenobarbital
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.