About safinamide
Monoamine oxidase-B inhibitor
Used for
- Add-on treatment for Parkinson’s disease with levodopa/carbidopa, with or without other Parkinson’s medicines.
Usual adult dose
Usually 50 mg once daily; may increase to 100 mg once daily.
Common side effects
- Involuntary movements (dyskinesia)
- Falls
- Nausea
- Insomnia
Important warnings
- Can cause or worsen uncontrolled movements, hallucinations, or sudden sleepiness.
- May cause high blood pressure, especially with certain medicines or foods rich in tyramine.
- Do not combine with other MAO inhibitors, opioids such as tramadol, or certain antidepressants.
- Do not use with severe liver disease; dose limits apply in moderate liver disease.
Pregnancy
Limited human information; generally avoided unless a specialist considers treatment essential.
Breastfeeding
Unknown whether safinamide passes into breast milk; breastfeeding is generally not recommended during treatment.
Interactions
- Other MAO inhibitors and some antidepressants can cause serious reactions.
- Opioids, including tramadol and methadone, may cause serious interactions.
- Dextromethorphan may cause confusion or abnormal behavior.
- Strong CYP3A4 inducers, such as rifampicin, may reduce safinamide effects.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.