About piperacillin sodium + tazobactam sodium
Extended-spectrum penicillin and beta-lactamase inhibitor
Used for
- Serious infections of the lungs, abdomen, skin, or urinary tract
- Bloodstream infections caused by susceptible bacteria
- Infections involving susceptible Pseudomonas bacteria
Usual adult dose
Usually 3.375–4.5 g intravenously every 6–8 hours; dose depends on infection and kidney function.
Usual dose in children
For children aged 2 months or older: typically 80–100 mg/kg piperacillin intravenously every 6–8 hours, with a maximum of 4 g piperacillin per dose; specialist dosing varies.
Common side effects
- Diarrhea, nausea, or vomiting
- Rash or allergic reactions
- Low blood cell counts
- Kidney or liver test abnormalities
Important warnings
- Serious allergic reactions can occur, especially with penicillin or cephalosporin allergy.
- Dose adjustment may be needed for impaired kidney function.
- Prolonged treatment can cause bleeding, low blood counts, or severe antibiotic-associated diarrhea.
- Use only for susceptible bacterial infections; unnecessary use promotes resistance.
Pregnancy
May be used when clinically needed; human pregnancy data are limited, so treatment should be assessed by a clinician.
Breastfeeding
Small amounts may pass into breast milk; monitor for infant diarrhea, thrush, or rash.
Interactions
- May increase bleeding risk with warfarin or other anticoagulants.
- May increase kidney injury risk with vancomycin.
- Can interact with methotrexate by reducing its clearance.
- May affect laboratory test results, including urine glucose tests.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.