About ambrisentan
Endothelin receptor antagonist
Used for
- Treats pulmonary arterial hypertension (PAH) to improve exercise ability and delay worsening.
- May be combined with tadalafil for PAH in suitable adults.
Usual adult dose
5 mg once daily; may increase to 10 mg once daily. Often combined with tadalafil.
Common side effects
- Swelling, especially in the legs or ankles
- Headache
- Nasal congestion or sinus symptoms
- Anemia
Important warnings
- Can cause serious harm to an unborn baby; pregnancy is contraindicated.
- Pregnancy testing and effective contraception are required during treatment and for one month afterward.
- May cause fluid retention, worsening heart failure, or reduced blood counts.
- Liver injury is possible; liver tests may be needed.
Pregnancy
Contraindicated; can cause severe birth defects. Avoid during pregnancy.
Breastfeeding
Whether ambrisentan passes into breast milk is unknown; breastfeeding is generally not recommended during treatment.
Interactions
- Cyclosporine increases ambrisentan exposure; the ambrisentan dose should not exceed 5 mg daily with it.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.