About pyrazinamide
Antituberculosis antibiotic
Used for
- Treats tuberculosis as part of combination therapy with other medicines.
Usual adult dose
Usually 20–30 mg/kg once daily, or 50–70 mg/kg three times weekly; specialist-directed.
Usual dose in children
Usually 30–40 mg/kg once daily, or 50 mg/kg three times weekly; specialist-directed.
Common side effects
- Liver inflammation or damage
- Nausea, vomiting, or loss of appetite
- Joint pain
- Increased uric acid, sometimes causing gout
Important warnings
- Use only with other tuberculosis medicines.
- Requires liver-function monitoring; serious liver injury can occur.
- Report yellow skin, dark urine, or persistent nausea promptly.
- Use cautiously with liver disease, gout, or kidney impairment.
Pregnancy
Use only when needed for tuberculosis treatment; clinicians weigh benefits and risks.
Breastfeeding
Small amounts may enter breast milk; tuberculosis treatment decisions require clinical guidance.
Interactions
- May increase liver-injury risk with other liver-toxic medicines.
- Can increase blood uric acid and worsen gout.
- May affect cyclosporine levels; monitoring may be needed.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.