About cilastatin + vial cilastatin sodium + vial relebactam + vial relebactam monohydrate + vial imipenem + vial imipenem monohydrate + vial
Carbapenem antibiotic with beta-lactamase inhibitor
Used for
- Treats certain complicated urinary tract infections, including kidney infections.
- Treats certain complicated abdominal infections, alongside other antibiotics.
- Treats hospital-acquired and ventilator-associated bacterial pneumonia.
Usual adult dose
500 mg imipenem / 500 mg cilastatin / 250 mg relebactam intravenously every 6 hours; adjust for kidney function.
Common side effects
- Nausea, diarrhea, vomiting, or infusion-site reactions
- Headache, rash, or abnormal liver tests
- Seizures, especially with kidney problems or brain disorders
Important warnings
- Use only for susceptible bacterial infections; it does not treat viral illnesses.
- Serious allergic reactions may occur, especially with beta-lactam antibiotic allergy.
- Kidney impairment requires dose adjustment; monitor for seizures.
- May cause Clostridioides difficile-associated diarrhea.
Pregnancy
Human pregnancy data are limited; use when clearly needed after clinical assessment.
Breastfeeding
Unknown whether the components enter human milk; consider infant monitoring for diarrhea or thrush.
Interactions
- Valproic acid or divalproex levels may fall, increasing seizure risk.
- Ganciclovir may increase seizure risk.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.