About cefoxitin sodium
Second-generation cephalosporin antibiotic
Used for
- Treats serious infections caused by susceptible bacteria, including abdominal, pelvic, and skin infections.
- Used to prevent infection during certain surgeries.
Usual adult dose
Usually 1–2 g intravenously or intramuscularly every 6–8 hours; dose depends on infection and kidney function.
Usual dose in children
Usually 80–160 mg/kg/day intravenously or intramuscularly, divided every 4–6 hours; maximum 12 g daily.
Common side effects
- Diarrhea, nausea, or vomiting
- Injection-site pain or inflammation
- Rash or itching
- Changes in blood counts or liver tests
Important warnings
- Serious allergic reactions can occur, especially with cephalosporin allergy.
- Dose adjustment may be needed with kidney impairment.
- Antibiotics can cause severe, persistent diarrhea from intestinal infection.
- Use only for bacterial infections; unnecessary use encourages resistance.
Pregnancy
Human pregnancy data are limited. Use when a clinician considers treatment necessary.
Breastfeeding
Small amounts may enter breast milk; infant diarrhea or thrush is possible.
Interactions
- Probenecid can increase cefoxitin levels.
- Warfarin and other anticoagulants may have increased bleeding effects.
- Aminoglycosides may increase kidney injury risk, especially with impaired kidney function.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.