About spironola ctone
Potassium-sparing diuretic; aldosterone antagonist
Used for
- Heart failure and fluid retention
- High blood pressure
- Excess aldosterone (hyperaldosteronism)
- Certain cases of low potassium
Usual adult dose
Often 25–100 mg daily for heart failure or fluid retention; dose varies by condition and kidney function.
Usual dose in children
For selected uses, usually 1–3 mg/kg daily in one or divided doses; specialist-directed.
Common side effects
- High potassium
- Dizziness or low blood pressure
- Breast enlargement or tenderness
- Menstrual changes
Important warnings
- Can cause dangerously high potassium, especially with kidney problems.
- Monitoring of potassium and kidney function is important.
- May cause dehydration or worsening kidney function.
- Seek urgent care for severe weakness, palpitations, or fainting.
Pregnancy
Generally avoided, particularly because of potential effects on fetal sex development; use only when a clinician considers it essential.
Breastfeeding
Spironolactone enters milk in small amounts; generally considered compatible with breastfeeding when prescribed.
Interactions
- Potassium supplements and potassium-containing salt substitutes increase high-potassium risk.
- ACE inhibitors, ARBs, and aliskiren can increase potassium.
- NSAIDs may worsen kidney function and reduce its effect.
- Lithium levels may rise.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.