About pralidoxime chloride
Cholinesterase reactivator antidote
Used for
- Treatment of poisoning by organophosphate insecticides or nerve agents
- Used with atropine for cholinergic symptoms
Usual adult dose
Commonly 1–2 g intravenously over 15–30 minutes; repeat or continue infusion according to response and poisoning severity.
Usual dose in children
Commonly 20–50 mg/kg intravenously over 15–30 minutes; repeat or continue infusion according to response and poisoning severity.
Common side effects
- Fast heartbeat or high blood pressure
- Dizziness, headache, or blurred vision
- Nausea
- Muscle weakness
Important warnings
- Emergency treatment; give with atropine when indicated.
- Rapid injection can cause serious blood pressure or heart rhythm changes.
- Dose and duration depend on the poison and clinical response.
- Use caution with kidney impairment.
Pregnancy
Use for serious poisoning when needed; untreated poisoning can endanger both pregnant person and fetus.
Breastfeeding
Human data are limited; treatment may be necessary for life-threatening poisoning.
Interactions
- Anticholinesterase medicines, including neostigmine and pyridostigmine, may have opposing effects.
- Other medicines affecting heart rate or blood pressure may increase monitoring needs.
AI-generated from general medical knowledge, not from this product's official leaflet. It may be incomplete or out of date. Not medical advice — ask a pharmacist or doctor before making any decision.